Comparing Statistical Metrics for Differential Network Analysis
C. Ruiz de Porras Rubio, A. Sánchez Pla, C. Andrés-Lacueva, D. Garrido-Martín, A. Miñarro Alonso
Network analysis is a powerful tool in biology, medicine, and social sciences for studying complex systems, with nodes representing entities and edges their interactions. In this work, networks are constructed from partial correlation matrices, where edges represent associations between pairs of variables conditional on all others. Changes in networks help reveal pathological mechanisms and system responses to external stimuli. Differential network analysis compares structures under different conditions, detecting shifts in connections beyond individual node expression. This study evaluates statistical metrics on simulated weighted matrices using permutation tests, showing that Frobenius distance, Invariant Network Structure, L1-norm and Correlation distance effectively detect subtle structural differences. Applied to real data, the approach identifies significant changes between experimental conditions.
Palabras clave: Partial correlation networks, Differential network analysis, Permutation tests, Distance metrics, Weighted matrices, Power analysis
Programado
Sesión de pósters II
4 de septiembre de 2026 09:00
Facultade de Ciencias Económicas e Empresariais
Otros trabajos en la misma sesión
M. Á. Montero Alonso, A. Ruiz Vega, J. M. Melchor Rodríguez, J. D. Luna del Castillo
L. Núñez González, B. Temes Álvarez, A. Urisarri Ruiz de Cortázar, M. Gil Calvo, A. M. Barcia de la Iglesia, P. Oliveros Martínez, N. Carrera Cachaza, M. Á. García González, M. García Murias
N. Montiel, C. Pérez-Carral, P. J. Hidalgo, M. Ortega-Moreno, M. Ortega Moreno
L. Padrón Blanco
C. Patino Alonso, J. L. Molina González, F. Espejo Almodóvar, S. Zazo del Dedo, M. C. Molina González
P. Perez Fernandez, A. García Nogales
A. Pérez González, M. Conde Amboage
M. C. Robustillo, L. Naranjo, M. I. Parra Arévalo, J. Hernández, C. J. Pérez Sánchez
C. R. Palmero, J. P. RINCÓN-ZAPATERO
M. Rodríguez Barreiro, M. L. Carpente Rodríguez, S. Lorenzo Freire
I. Rodríguez Martín, H. Yaman
J. Segura Gisbert, J. F. Morala Girón
M. Flores Sánchez, M. Soliz Villafuerte, S. Naya Fernández, J. Tarrío Saavedra
J. Proaño, M. Flores, J. Tarrío Saavedra, S. Naya
J. M. Sarabia Alegria, V. Jordá, M. Tejería-Martínez
M. Vallejo Pascual, M. Martínez Pizarro, P. Blanco Alonso
M. C. Vega Hernández, M. L. Pérez-Delgado, J. Á. Román-Gallego, M. Á. Conde González
M. J. Rivas Lopez, J. M. Sánchez-Santos, A. Berral-González, M. M. Arroyo, J. De las Rivas Sanz